报告题目：Engineering the Molecular Dynamics of Polymeric Biomaterials for Regulating Cellular Functions
报告人：边黎明副教授
报告时间：2018年11月8日（星期四）下午17:00-18:00
报告地点：友谊校区老图书馆401室
邀请人：李鹏教授
报告简介：The dynamic properties of polymeric biomaterials at molecular level impart significant impact on the cellular behaviors. Developing tunable molecularly-dynamic polymeric biomaterials is highly instrumental to the fundamental investigation on cellular responses to the dynamic cues in extracellular environment. For example, cellular adhesion is controlled by the dynamic ligation process of surface receptors, such as integrin, to adhesive motifs, such as Arg-Gly-Asp (RGD). Remote control of adhesive ligand presentation on biomaterial surfaces can offer benefits in regulating cell-implant interactions, thereby immune responses or tissue regeneration in vivo. Herein we present a strategy for modulating nanoscale ligand oscillations on 2D biomaterial substrates by adjusting the frequency of an oscillating magnetic field to modulate the adhesion and specialization of stem cells and macrophages. To investigate 3D culture of cells in hydrogels with dynamic network structures, we have developed a series of dynamic hydrogels based on reversible crosslinks with unique properties such as resilient mechanical property, fast relaxation, self-healing, bioadhesiveness, injectability, and promoting recruitment of endogenous cells. These hydrogel properties are not only desirable for potential clinical applications of these hydrogels but also useful for studying the effect of microenvironmental mechanical cues on stem cell behaviors.
报告人简介：边黎明，香港中文大学生物医学工程系，副教授。边教授分别于2002年及2004年在新加坡国立大学获得本科学士及生物工程硕士学位。2004年赴美哥伦比亚大学生物医学工程学系继续攻读博士学位。2009年获博士学位后，在宾夕法尼亚大学生物工程学系进行博士后研究。2012年夏开始就职于香港中文大学。边教授研究的主要方向是生物支架材料及纳米生物材料的设计及在干细胞组织工程方面的应用。具体的研究方向有仿生生物材料的设计开发，细胞微环境信息对干细胞行为的影响，多功能水凝胶的设计，纳米结构用于生物配体微观呈递，干细胞组织工程等。边教授的科研成果发表在PNAS，Biomaterials，Nano Letters，Advanced Functional Materials，JACS，ACS Nano，Advanced Materials，Advanced Science，Macromolecules，Chemistry of Materials等学术期刊杂志。
