报告题目：Opportunities for Porous Silicon in Nanomedicine

报告人：Nicolas Voelcker教授

讲座时间：2018年11月13日上午9：00

讲座地点：友谊校区老图书馆401

邀请人：李林 教授

承办单位：柔性电子研究院

联系人：王添

联系电话：18269103286

报告简介：

This talk will explore the application of nanostructured silicon including porous silicon and silicon nanowires in drug and gene delivery, optical and electrochemical biosensors and in regenerative medicine. These elemental silicon-based materials have high surface area of up to several hundreds of square meters per gram, facilitating loading of considerable amounts of bioactives. Second, pore size can be tailored over a wide range, spanning from the nano- to the microscale. Being able to 'dial in' a certain pore size allows for facile optimisation of topographical cues for attachment, guidance, proliferation and differentiation of target cells. At the same time, the rate of diffusive release of drugs can be tuned by adjusting the pore size. Third, the materials are biocompatible and biodegradable, with the nanostructured elemental silicon undergoing oxidative hydrolysis in aqueous medium at a rate that is easily tunable by means of the surface chemistry from hours to months. A diverse range of surface chemistries is available for this material, some of which are amenable to surface patterning, formation of surface-bound gradients and formation of silicon-polymer hybrid materials. Finally, thin films, membranes and particles of porous silicon display interferometric reflectance and photonic effects, which are responsive to binding of target biomolecules. This talk will first introduce nanostructured silicon material properties and fabrication and characterisation aspects, including describing strategies for nano- and microscale patterning and gradient formation. This will be followed by an overview of the work using porous silicon nanostructured films as optical and electrochemical transducers. Drug delivery applications for targeted cancer therapy, immunotherapy and the therapy of ocular diseases will be highlighted, and the use of nanostructured silicon in chronic wound diagnostics and theranostics will be discussed. Finally, the talk will provide an example of the use of porous carrier material for ocular cell therapy.

报告人简介：

Nicolas Voelcker教授于1999年获得博士学位（RWTH Aachen），并在Scrippts Research Institute从事博士后工作3年，师从M.R. Ghadiri教授。2001年Nico加入Flinders University，并在2008年提拔为教授以及理学院副院长。2012年Nico加入南澳大学（University of South Australia），并于同年成为Mawson Institute院长。2017年Nico加入莫纳什（Monash）大学药学院（药剂药理学世界排名第二），并与同年成为Melbourne Centre for Nanofabrication (墨尔本纳米中心，MCN)院长以及澳大利亚联邦科学与工业研究组织(CSIRO)科研领头人。他同时还担任莫纳什大学工程与材料学院教授，以及Leibniz Institute for New Materials（德国）客座教授，University Rovira I Virgili（西班牙）客座教授。他还是澳大利亚皇家化学学会，和英国皇家化学学会理事。

Nico在生物纳米材料和生物表面材料上作出了许多贡献。在多孔硅纳米材料（Porous Silicon Nanoparticles, pSiNPs）的生物应用上Nico作出了开创性研究（超过100篇高质量文章），并享有极高的国际声誉（多孔硅材料世界前五）。他还设计了多孔硅传感器，利用材料特质从而提高了信号强度。Nico还在纳米针以及纳米线上发表了多篇高质量文章。迄今为止Nico共发表了350篇学术论文，10本书以及25项专利，总引数超过7500次，年引用次数超过1100次/年，h-index 49，其中包括国际学术期刊Nature Communication, Nature Nanotechnology, Advanced Material, Advanced Functional Material以及Biometerial等。Nico已经获得了十余项奖项，包括南澳年度科学家（2015）。